Research Interests
Anthony Coates is the Professor of Medical Microbiology at St Georges, University of London. His long term research interest is in tuberculosis, and is currently concentrating on the latent form of the disease. Arising from this research, he has invented with Dr Yanmin Hu, a new way of making novel antibiotics. The first of these new antibiotics is now in clinical trials.
Publications
1.Hu Y, Shamaei-Tousi A, Liu Y, Coates AR (2010) A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for
Staphylococcal infections. PLoS ONE . 2010 Jul 27;5(7):e11818
2. Cehovin A, Coates AR, Hu Y, Riffo-Vasquez Y, Tormay P, Botanch C, Altare F, Henderson B (2010) Comparison of the moonlighting actions of the two highly homologous chaperonin 60 proteins of Mycobacterium tuberculosis. Infect Immun, April 2010.
3. Henderson B, Lund PA, Coates ARM (2010) Multiple moonlighting functions of mycobacterial molecular chaperones. Tuberculosis, 90: 119-124.
4. Hu Y, van der Geize R, Besra GS, Gurcha SS, Liu A, Rohde M, Singh M, Coates A (2010) 3-Ketosteroid 9?-hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis. Molecular Microbiology, 75(1), 107-121.
5. Henderson B, Calderwood SK, Coates AR, Cohen I. van Eden W, Lehner T, Pockley AG (2010) Caught with their PAMPs down? The extracellular signalling actions of molecular chaperons are not due to microbial contaminants. Cell Stress Chaperones, 15(2): 123-141.
6. Hu Y, Coates A (2009) Acute and persistent Mycobacterium tuberculosis infections depend on the Thiol Peroxidase TPX. PLoS ONE, 4(4), e5150.
7. Coates T, Bax R, Coates ARM (2009) Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects. J Antimicrobial Chem, 64: 9-15.
8. Barford JMT, Coates ARM (2009) The pathogenesis of catheter-associated urinary tract infection. Journal of Infection Prevention, 10 (2): 50-56.
9. Winrow VR, Mesher J, Meghji S, Morris CJ, Maguire M, Fox S, Coates ARM, Tormay P, Blake DR, Henderson B (2008) The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts. Cellular Microbiology, 10 (10), 2091-2104.
10. Hu Y, Henderson B, Lund PA, Tormay P, Tabish Ahmed M, Gircja SS, Besra GS, Coates ARM (2008) A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection. Infect Immun, 76 (4), 1535-1546.
11. Wang M, Karlsson C, Olsson C, Adlerberth I, Wold AE, Strachan DP, Martricardi P, Aberg N, Perkin MR, Tripodi S, Coates AR, Hesselmar B, Saalman R, Molin G, Ahrne S (2008) Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immun, 121(1), 129-134.
12. Adlerberth I, Strachan DP, Matricardi PM, Ahrne S, Orfei L, Aberg M. Perkin MR, Tripodi S, Hesselmar B, Saalman R, Coates AR, Bonnano C, Panetta V, Wold AE (2007) Gut microbiota and development of atopic eczema in three European birth cohorts. J Allergy Clin Immun, 120, 343-350 .
13. Shamaei-Tousi A, Stephens JW, Bin R, Cooper JA, Steptoe A, Coates ARM, Henderson B, Humphries SE (2006) Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus. Eur Heart J, 27: 1565-1570.
14. Hu Y, Movahedzadeh F, Stoker NG, Coates ARM (2006) Deletion of the Mycobacterium tuberculosis á-crystallin-like hspX gene causes increased bacterial growth in vivo. Infection & Immunity, 74: 861-868.
15. Tormay P, Coates ARM, Henderson B (2005) The intercellular signalling activity of the Mycobacterium tuberculosis chaperonin 60.1 protein resides in the equatorial domain. J Biol Chem, 280: 14272-14277.
16. Coates A, Hu Y, Bax R, Page C (2002) The future challenges facing the development of new antimicrobial drugs. Nature Reviews, 1: 895-910.
17. Hu Y, Mangan JA, Dhillon J, Sole KM, Mitchison DA, Butcher PD, Coates ARM (2000), Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide. J Bact, 182 (22): 6358-6365.
18. Meghji S, White PA, Nair SP, Reddi K, Heron K, Henderson B, Zaliani A, Fossati G, Mascagni P, Hunt JF, Roberts MM, Coates ARM (1997) Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: A potential contributory factor in Pott s disease. J Exp Med, 186
Remaining publications 2008-1997:
19. Barford JMT, Hu Y, Anson K, Coates ARC (2008) A biphasic response from bladder epithelial cells induced by catheter material and bacteria. An in vitro study into the pathophysiology of catheter-related urinary tract infection. J Urol (in press).
20. Barford JM, Anson K, Hu Y, Coates AR (2008) A model of catheter-associated urinary tract infection initiated by bacterial contamination of the catheter tip. BJU Int, 102: 67-74.
21. Coates AR, Hu Y (2008) Targeting non-multiplying organisms as a way to develop novel antimicrobials. Trends Pharmacol Sci, 29(3), 143-150.
22. Hu Y, Coates ARM, Mitchison DA (2008) Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis. Int J Tuberc Lung Dis, 12(1), 69-73.
23. Coates AR, Hu Y (2007) Novel approaches to developing new antibiotics for bacterial infections. Br J Pharmacol, 152(8), 1147-1154.
24. Shamaei-Tousi A, D’Aiuto F, Nibali L, Steptoe A, Coates ARM, Parkar M, Donod N, Henderson B (2007) Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease. PLoS One, 2(11), e1198.
25. Shamaei-Tousi A, Steptoe A, O’Donnell K, Palmen J, Stephens J, Hurel S, Marmot M, Homer K, D’Auito F, Coates A, Humphries S, Henderson B (2007) Plasma heat shock protein 60 and cardiovascular disease risk: the effect of psychosocial, genetic and biological factors. Cell Stress & Chaperones, 12(4): 384-392.
26. Steptoe A, Shamaeri-Tousi A, Gylfe A, Bailey L, Bergstrom S, Coates AR, Henderson B (2007) Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens. Clin Vaccine Immunol 14(2): 204-207.
27. Lewthwaite JC, Clarkin CE, Coates AR, Poole S, Lawrence RA, Wheeler-Jones CP, Pitsillides AA, Singh M, Henderson B (2007) Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases. Int Immunopharmacol, 7(2): 230-240.
28. Coates AR, Hu Y (2006) New strategies for antibacterial drug design: targeting non-multiplying latent bacteria. Drugs R D, 7(3): 133-151.
29. Henderson B, Allan E, Coates AR (2006) Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection. Infect Immun, 74: 3693-3706.
30. Hu Y, Coates AR, Mitchison DA (2006) Sterilising action of pyrazinamide in models of dormant and rifampicin-tolerant Mycobacterium tuberculosis. Int J Tuberc Lung Dis, 10(3): 317-322.
31. Maguire M, Poole S, Coates AR, Tormay P, Wheeler-Jones C, Henderson B (2005) Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes. Immunology, 115: 231-238.
32. Qamra R, Mande SC, Coates ARM, Henderson B (2005) The unusual chaperonins of Mycobacterium tuberculosis. Tuberculosis, 85: 385-394.
33. Halcox JPJ, Shamaei-Tousi A, Henderson B, Steptoe A, Coates ARM, Singhal A, Lucas A, Deanfield J (2005) Circulating human heat shock protein 60 in the blood of healthy teenagers: a novel determinant of endothelial dysfunction and early vascular injury. Arterioscler Thromb Basc Biol, 25: 141-142 (IF 7.4).
34. Hu Y, Coates ARM (2005) Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coli. FEMS Microbiology Letters, 243: 117-124.
35. Riffo-Vasquez Y, Spina D, Page C, Tormay P, Singh M, Henderson B, Coates A (2004) Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation. Clin Exp Allergy, 34: 712-719.
36. Hu Y, Kendall S, Stoker NG, Coates ARM (2004) The Mycobacterium tuberculosis sigJ gene controls sensitivity of the bacterium to hydrogen peroxide. FEMS Microbiology Letters, 237: 415-423.
37. Mitchison DA, Coates ARM (2004) Predictive in vitro models of the sterilizing activity of anti-tuberculosis drugs. Current Pharmaceutical Design, 10: 3285-3295.
38. Fossati G, Cremonesi P, Izzo G, Rizzi E, Sandrone G, Harding S, Errington N, Walters C, Henderson B, Roberts MM, Coates ARM, Mascagni P (2004) The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticity. Biopolymers, 75: 148-162.
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