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Consultant in Infectious Diseases, Addenbrooke’s Hospital, Cambridge
MA, MBBS, MRCP, FRCPath
Research interests
Estee Torok qualified in Medicine from the Universities of Oxford and London. She completed her postgraduate medical training in Oxford and then spent a year as a Clinical Research Fellow in the Department of Medicine, Imperial College doing hepatitis C research. She trained in Infectious Diseases and Medical Microbiology in Oxford. From 2004 to 2008 she was a Wellcome Training Fellow at the Oxford University Clinical Research Unit in Vietnam where she did her PhD research in HIV-associated TB meningitis. In 2009 she was appointed as a Consultant in Infectious Diseases at Addenbrooke’s Hospital, Cambridge. Her research interests are clinical trials, HIV, tuberculosis, CNS infections, and viral hepatitis.
Publications
1. ME Török, NTB Yen, TTH Chau, NTH Mai, NH Phu, PP Mai, NT Dung, NVV Chau, ND Bang, NA Hien, NH Minh, NQ Hien, PVK Thai, DT Dong, DTT Oanh, NTC Thoa, NN Lan, NTN Lan, HT Quy, NH Dung, TT Hien, NT Chinh, CP Simmons, MD de Jong, M Wolbers, JJ Farrar. Timing of initiation of antiretroviral therapy in human immunodeficiency virus-associated tuberculous meningitis. Clin Infect Dis. 2011 Jun; 52(11):1374-83.
2.T Pouplin, J Nguyen Pouplin, PV Toi, N Lindegardh, HR van Doorn, TT Hien, J Farrar, ME Török, TTH Chau. Valacyclovir for herpes simplex encephalitis. Antimicrob Agents Chemother. 2011 Jul;55(7):3624-6.
3. GE Thwaites, SM Bhavnani, TTH Chau, JP Hammel, ME Török, SA Van Wart, PP Mai, DK Reynolds, M Caws, NT Dung, TT Hien, R Kulawy, J Farrar, PG Ambrose. A randomised pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis. Antimicrob Agents Chemother. 2011 Jul;55(7):3244-53
4. GE Thwaites, JD Edgeworth, E Gkrania-Klotsas, A Kirby, ME Török, R Tilley, S Walker, HFL Wertheim, P Wilson, MJ Llewelyn; on behalf of the United Kingdom Clinical Infection Research Group (UKCIRG). Do we know how to manage Staphylococcus aureus bacteraemia? Lancet Infect Dis. 2011 Mar; 11(3):208-222.
5. SD Lawn, ME Török, R Wood Timing of antiretroviral therapy in HIV-associated opportunistic infections. Curr Opin Infect Dis. 2011; 24(1):34-42.
6. G.E.Thwaites; UK Clinical Infection Research Group. The management of Staphylococcus aureus bacteraemia in the United Kingdom and Vietnam: a multi-centre evaluation PLoS One. 2010 Dec 13;5(12):e14170
7. The First Report of Salmonella Paratyphi A Azithromycin Resistance Leading to Treatment Failure. A Molloy, S Nair, FJ Cooke, J Wain, M Farrington, PJ Lehner, ME Török. J Clin Microbiol. 2010 Dec;48(12):4655-7. Epub 2010 Oct 13
8. S Marais, DJ Pepper, BJ Marais, ME Török. HIV-associated tuberculous meningitis – diagnostic and therapeutic challenges. Tuberculosis (Edinb). 2010 Nov;90(6):367-74. Epub 2010 Sep 28
9. S Marais, G Thwaites, J Schoeman, ME Török, UK Misra, K Prasad, P Donald, RJ Wilkinson, Ben Marais. Tuberculous Meningitis: defining a uniform case definition for use in clinical research Lancet Infect Dis. 2010 Nov;10(11):803-12. Epub 2010 Sep 6.
10. ME Török, A Chapman, A Lessing, F Sanderson, RA Seaton. Advances in Outpatient Parenteral Antimicrobial Therapy. Curr Opin Investig Drugs. 2010 Aug;11(8):929-39.
11. ME Torok, A Kambugu, E Wright. Immune reconstitution disease of the central nervous system. Curr Opinions HIV/AIDS 2008; 3: 438 – 445.
12. M Caws, G Thwaites, S Dunstan, T Hawn, NTN Lan, NTT Thuong, K Stepniewska, MNT Huyen, ND Bang, TH Loc, S Gagneux, D van Soolingen, K Kremer, M van der Sande, P Small, PTH Anh, NT Chinh, HT Quy, DQ Tho, E Torok, TT Hien, NH Dung, NTQ Nhu, PM Duy, NVV Chau, J Farrar. The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog 2008; 4(3):e1000034.
13. G Thwaites, M Caws, TTH Chau, A D’Sa, NTN Lan, MNT Huyen, S Gagneux, PTH Anh, DQ Tho, E Torok, NTQ Nhu, NTH Duyen, PM Duy, J Richenberg , C Simmons, TT Hien, J Farrar. The relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis. J Clin Microbiol. 2008;46(4):1363-8
14. ME Torok, Chau TTH, Mai PP, Phong ND, Dung NT, Chuong LV, Sue J Lee, M Caws, M de Jong, Hien TT, Farrar JJ. Clinical and microbiological features of HIV-associated tuberculous meningitis in Vietnamese adults. PLoS ONE. 2008 Mar 19;3(3):e1772.
15. Caws M, Ha DTM, Torok E, Campbell J, Thu DD, Chau TT, Van Vinh Chau N, Chinh NT, Farrar JJ. Evaluation of the MODS culture technique for the diagnosis of tuberculous meningitis. PLoS ONE 2007 Nov 14;2(11): e1173.
16. NTH Mai, TTH Chau, GThwaites, LV Chuong, DX Sinh, HDT Nghia, PQ Tuan, ND Phong, NH Phu, TS Diep, NVV Chau, NM Duong, J Campbell, C Schultsz, C Parry, ME Torok, NJ White, NT Chinh, TT Hien, K Stepniewska, JJ Farrar. A randomized controlled trial of dexamethasone for Vietnamese adolescents and adults with bacterial meningitis. New Engl J Med 2007; 357: 2431 – 40.
17. ME Torok, HDT Nghia, TTH Chau, NTH Mai, GE Thwaites, K Stepniewska, JJ Farrar. Evaluation of a diagnostic algorithm for adult tuberculous meningitis. Am J Trop Med Hyg 2007; 77(3): 555-559.
18. Caws M, Tho DQ, Duy PM, Lan NT, Hoa DV, Torok ME, Chau TT van Vinh Chau N, Chinh NT, Farrar J. PCR-restriction fragment length polymorphism for rapid, low-cost identification of isoniazid-resistant Mycobacterium tuberculosis. J Clin Microbiol. 2007 Jun; 45(6):1789-93.
19. ME Torok. CNS infectious diseases research 2006: clinical advances and emerging threats. Lancet Neurology 2007; 6: 16-18.
20. Simmons CP, Thwaites GE, Quyen NT, Torok E, Hoang DM, Chau TT, Mai PP, Lan NT, Dung NH, Quy HT, Bang ND, Hien TT, Farrar J. Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. J Immunol. 2006 Feb 1;176(3):2007-14.
21. ME Torok. Human immunodeficiency virus associated central nervous system infections. Practical Neurology 2005: 5; 334-349.
22. ME Torok, JN Day, TT Hien, JJ Farrar. Immediate or delayed antiretroviral therapy for central nervous system opportunistic infections? AIDS 2005; 19(5): 535-6.
23. Wright M, Forton D, Main J, Goldin R, Torok E, Tedder R, Grant P, Thursz M, Naoumov N, Millson C, Mills PR, Bassendine M, Thomas HC; on behalf of the UK Mild HCV Trial investigators. Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trial. J Viral Hepat. 2005 (1): 58-66.
24. M Leyland, ME Torok, J Acheson and GR Foster. Hepatitis C virus infection is not associated with ophthalmic morbidity Eye 2000; 14: 889-91.
25. HC Thomas, ME Torok, DM Forton, and SD Taylor-Robinson. Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C. J Hepatology 1999; 31 Suppl 1: 152-9.
26. HC Thomas and ME Torok. Current views on the pathogenesis and treatment of chronic hepatitis B and hepatitis C virus infections and the use of mathematical modelling as a basis for planning new therapeutic approaches. Horizons in Medicine 1999; vol 11.
27. HC Thomas, ME Torok, GR Foster. Hepatology Elsewhere: Hepatitis C virus dynamics and the antiviral efficacy of interferon alfa therapy. Hepatology 1999; 29 (4): 3.
28. MR Thursz, D Kwiatowski, ME Torok, CEM Allsopp, BM Greenwood, HC Thomas and AVS Hill. Association of hepatitis B surface antigen carriage with severe malaria in Gambian children. Nature Medicine 1995; 1 (4) 374-5.
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