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Dr Tim McHugh is a Reader in Medical Microbiology within the Department of Infection at University College London (UCL).
Publications
A selection of recent publications:
1. Coxon Geoffrey D., Cooper Christoper B., Gillespie Stephen H., McHugh Timothy D. Strategies and challenges involved in the discovry of new chemical entities during early-stage tuberculosis drug discovery. Journal of Infectious Diseases 2012; doi: 10.1093/infdis/jis191
2. Zumla A, Abubaker I, Raviglione M, Hoelscher M, Ditiu L, McHugh TD, Squire Sb, Cox H, Ford N, McNerney R, MaraisBJ, Grobusch MP, Lawn SD, Migliori GB, Mwaba P, O'Grady J, Pletschette M, Ramsay A, Chakaya J, Schito ML, Swaminathan S, Memish Z, Maeurer M, ATun R. Drug-reststant tuberculosis -Current dilemmas, unanswered quesions, challenges, and priority needs. Journal of Infectious Disease 2012;
3. Phillips PPJ, Gillespie SH, Boeree M, Heinrich N, Arnouste R, McHugh TD,Pletschette M, Lienhardt C, Hafner R, Mgone C, Zumla A, Nunn AJ and Hoelscher M. Innovative Trial Designs are Pratical Solutions for Improving the Treatment of Tuberculosis. Journal of Infectious Disease 2012; doi:10.1093/infdis/jis041
4.Osman K,Evangelopoulos D,Basavannacharya C,Gupta A,McHugh TD,Bhakta S,Gibbons S An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis.
Journal article 2012
5.Honeyborne I, McHugh TD, Phillips PP, Bannoo S, Bateson A, Carroll N, Perrin FM, Ronacher K, Wright L, van Helden PD, Walzl G, Gillespie SH (2011). Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment.. J Clin Microbiol, 49(11), 3905 - 3911. doi:10.1128/JCM.00547-11
6.Guzman JD, Wube A, Evangelopoulos D, Gupta A, Hüfner A, Basavannacharya C, Rahman MM, Thomaschitz C, Bauer R, McHugh TD, Nobeli I, Prieto JM, Gibbons S, Bucar F, Bhakta S (2011). Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics.. J Antimicrob Chemother, 66(8), 1766 - 1772. doi:10.1093/jac/dkr203
7.Perrin FM, Woodward N, Phillips PP, McHugh TD, Nunn AJ, Lipman MC, Gillespie SH. Radiological cavitation, sputum mycobacterial load and treatment response in pulmonary tuberculosis. Int J Tuberc Lung Dis. 2010; 14:1596-602.
8.O Sullivan DM, McHugh TD, Gillespie SH. Mapping the fitness of Mycobacterium tuberculosis strains: a complex picture. J Med Microbiol. 2010; 59:1533-5.
9.Pope CF, McHugh TD, Gillespie SH. Methods to determine fitness in bacteria Methods Mol Biol. 2010;642:113-21.
10.Pope CF, Gillespie SH, Moore JE, McHugh TD. Approaches to measure the fitness of Burkholderia cepacia complex isolates. J Med Microbiol. 2010; 59:679-86
11.Perrin FM, Breen RA, McHugh TD, Gillespie SH, Lipman MC Are patients on treatment for pulmonary TB who stop expectorating sputum genuinely culture negative? Thorax. 2009;64:1009-10
12.Al-Balas Q, Anthony NG, Al-Jaidi B, Alnimr A, Abbott G, Brown AK, Taylor RC, Besra GS, McHugh TD, Gillespie SH, Johnston BF, Mackay SP, Coxon GD Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH PLoS One. 2009;4(5):e5617.
13.Jenkins C, Bacon J, Allnutt J, Hatch KA, Bose A, O Sullivan DM, Arnold C, Gillespie SH, McHugh TD. Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH J Antimicrob Chemother. 2009 Jun;63(6):1118-20
14.O Sullivan DM, Hinds J, Butcher PD, Gillespie SH, McHugh TD. Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin. J Antimicrob Chemother. 2008;62:1199-202.
15.O Sullivan DM, McHugh TD, Gillespie SH. The effect of oxidative stress on the mutation rate of Mycobacterium tuberculosis with impaired catalase/peroxidase function. J Antimicrob Chemother. 2008;62:709-12
16.Davies AP, Dhillon AP, Young M, Henderson B, McHugh TD, Gillespie SH Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue. Tuberculosis (Edinb). 2008;88:462-8
17.Pope CF, O Sullivan DM, McHugh TD, Gillespie SH. A practical guide to measuring mutation rates in antibiotic resistance Antimicrob Agents Chemother. 2008;52:1209-14
18.Pope CF, Gillespie SH, Pratten JR, McHugh TD. Fluoroquinolone-resistant mutants of Burkholderia cepacia. Antimicrob Agents Chemother. 2008;52:1201-3.
19.O Sullivan DM, Sander C, Shorten RJ, Gillespie SH, Hill AV, McHugh TD, McShane H, Tchilian EZ. Evaluation of liquid culture for quantitation of Mycobacterium tuberculosis in murine models. Vaccine. 2007; 28;25:8203-5.
20.Breen RA, Barry SM, Smith CJ, Shorten RJ, Dilworth JP, Cropley I, McHugh TD,Gillespie SH, Janossy G, Lipman MC. (2007). The Clinical Application of a Rapid Lung-Orientated TB Immunoassay in Individuals with Possible Tuberculosis. Thorax
21.Perrin FM, Lipman MC, McHugh TD, Gillespie SH. (2007). Biomarkers of treatment response in clinical trials of novel antituberculosisagents. Lancet Infect Dis 7(7), 481-490
22.Williams KJ, Ling CL, Jenkins C, Gillespie SH, McHugh TD. (2007). A paradigm for the molecular identification of Mycobacterium species in a routinediagnostic laboratory. Journal of Medical Microbiology 56(5), 598-602.
23.Creer,D.D., Dilworth,J.P., Gillespie,S.H., Johnston,A.R., Johnston,S.L., Ling,C., Patel,S., Sanderson,G., Wallace,P.G., McHugh,T.D. (2006). Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care. Thorax 61(1), 75-79.
24.Cullen MM, Sam NE, Kanduma EG, McHugh TD, Gillespie SH. (2006). Direct detection of heteroresistance in Mycobacterium tuberculosis usingmolecular techniques. Journal of Medical Microbiology 55(8), 1157-58.
25.Paterson PJ, Seaton S, McHugh TD, McLaughlin J, Potter M, Prentice HG, KibblerCC. (2006). Validation and clinical application of molecular methods for the identificationof molds in tissue. Clinical Infectious Diseases 42(1), 51-56
27Uriyo J, Gosling RD, Maddox V, Sam NE, Schimana W, Gillespie SH, McHugh TD. (2006). Prevalences of Pneumocystis jiroveci, Mycobacterium tuberculosis andStreptococcus pneumoniae infection in children with severe pneumonia, in atertiary referral hospital in northern Tanzania. Ann Trop Med Parasitol. 100(3), 245-249
28.Batt,S.L., Charalambous,B.M., McHugh,T.D., Martin,S., Gillespie,S.H. (2005). Novel PCR-restriction fragement length polymorphism method to determine serotypes or serogroups of Streptococcus pneumoniae isolates. Journal of Clinical Microbiology 43(6), 2656-2661.
29.Dale, J.W., Bothamley, G.H., Drobniewski, F., Gillespie, S.H., McHugh, T.D., Pitman, R. (2005). Origins and properties of Mycobacterium tuberculosis isolates in London. Journal of Medical Microbiology 54(6), 575-582.
30.Gillespie,S.H., Basu,S., Dickens,A.L.,O\ Sullivan,D.M., McHugh,T.D. (2005). Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates. Journal of Antimicrobial Chemotherapy 56(2), 344-348.
31.Gillespie,S.H., Gosling,R.D., Uiso,L., Sam,N.E., Kanduma,E.G., McHugh,T.D. (2005). Early bactericidal activity of a moxifloxacin and isoniazid combination in smear-positive pulmonary tuberculosis. Journal of Antimicrobial Chemotherapy 56(6), 1169-1171.
32.Jenkins,C., Claxton,A.P., Shorten,R.J., McHugh,T.D., Gillespie,S.H. (2005). Rifampicin resistance in tuberculosis outbreak, London, England. Emerging Infectious Diseases 11(6), 931-934.
33.McHugh,T.D., Batt,S.L., Shorten,R.J., Gosling,R.D., Uiso,L., Gillespie,S.H. (2005). Mycobacterium tuberculosis lineage: a naming of the parts. Tuberculosis 85(3), 127-136.
34.O'Sullivan, D.M., McHugh, T.D., Gillespie, S.H. (2005). Analysis of rpoB and pncA mutations in the published literature:an insight into the role of oxidative stress inMycobacterium tuberculosis evolution? Journal of Antimicrobial Chemotherapy 55(5), 674-679.
35.Perrin,F.M., Breen,R.A., Lipman,M.C., Shorten,R.J., Gillespie,S.H., McHugh,T.D. (2005). Is there a relationship between Mycobacterium tuberculosis strain type and TB paradoxical reaction? Thorax 60(8), 706-707.
34.McHugh,T.D., Pope,C.F., Ling,C.L., Patel,P., Billington,O.J., Gosling,R.D., Lipman,M.C., Gillespie,S.H. (2004). Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. Journal of Medical Microbiology 53(12), 1215-1219.
36.Dale,J.W., Al Ghusein,H., Butcher,P., Dickens,A., Drobniewski,F., Forbes,K.J., Gillespie,S.H., Lamprecht,D., McHugh,T.D., Pitman,R., Rastogi,N., Smith,A.T., Sola,C., Yesilkaya,H. (2003). Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110. Journal of Applied Microbiology 185, 2555-2562.
37.Gillespie,S.H., Billington,O.J., Breathnach,A., McHugh,T.D. (2002). Multiple drug resistant tuberculosis: evidence for changing fitness on passage through human hosts. Microbial Drug Resistance 8, 1-7.
38.Maguire,H., Dale,J.W., McHugh,T.D., Butcher,P.D., Gillespie,S.H., Costetsos,A., Al Ghusein,H., Holland,R., Dickens,A., Marston,L., Wilson,P., Pitman,R., Strachan,D., Drobniewski,F.A., Banerjee,D.K. (2002). Molecular epidemiology of tuberculosis in London 1995-7 showing low rate of active transmission. THORAX 57(7), 617-622.
39.Melzer,M., Brown,T.J., French,G.L., Dickens,A., McHugh,T.D., Bagg,L.R., Storring,R.A., Lacey,S. (2002). Molecular analysis of drug resistant TB. THORAX 57(6), 562-563.
40.Ruddy,M., McHugh,T.D., Dale,J.W., Banerjee,D., Maguire,H., Wilson,P., Drobniewski,F., Butcher,P., Gillespie,S.H. (2002). Examination of the rate of unrecognized cross-contamination with Mycobacterium tuberculosis in London microbiology laboratories. Journal of Clinical Microbiology 40(11), 4100-4104.
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