TBD-UK is the UK's response towards the global effort to find new TB drugs.
kills around 2 million every year,
kills every 20 seconds,
infects 1/3 of the world's population and
it has not been eradicated.
Is a debilitating disease. It attacks lungs but it also cause much more severe complex symptoms. It affects the poor, the weak and co-exists with HIV/AIDS sufferers. 1/4 of all AIDS deaths are caused by TB.
is caused by Mycobacterium tuberculosis.
TB drugs work by killing this type of bacteria.
This is not easy and makes treatment long and difficult.
It takes 6-9 months to treat TB and now the drugs are beginning to be ineffective due to resistance.
We know more about TB now than we ever have done in the past!
Genetic information tells us what makes-up M. tuberculosis.
We can use this information to help us design new drugs.
Biochemical knowledge now tells us where we need to look and
we can use this to help design new drugs.
Medicinal chemists design and build many drug compounds.
Biochemists and microbiologists assess the compounds.
More compounds are made and tested again and again and again.......
From the bench to the clinic.....
New compounds from the laboratory are still a long way from the clinic.
They require years of rigorous safety and efficacy assessment in animals and in clinical trials.
This takes many years, is very expensive and sadly has a high rate of failure.
The new drugs we discover
must be safe,
must reduce treatment time,
should treat multiple resistant (MDR) TB,
should be compatible with HIV drugs,
should treat pediatric TB disease and
need to be affordable.
They are urgently needed!